Beethoven is back -- and this time, he has a whole brood with him now that he's met his canine match, Missy, and fathered a family. The only problem is that Missy's owner, Regina, wants to sell the puppies and tear the clan apart. It's up to Beethoven and the Newton kids to save the day and keep everyone together.
Two men from Pennsylvania give up hope in their small run down coal mining town, and head off in search of the beaches of California. The two steal cars as they travel across the USA and are joined by a wild young woman.
When Hong Kong Inspector Lee is summoned to Los Angeles to investigate a kidnapping, the FBI doesn't want any outside help and assigns cocky LAPD Detective James Carter to distract Lee from the case. Not content to watch the action from the sidelines, Lee and Carter form an unlikely partnership and investigate the case themselves.
A botched robbery indicates a police informant, and the pressure mounts in the aftermath at a warehouse. Crime begets violence as the survivors -- veteran Mr. White, newcomer Mr. Orange, psychopathic parolee Mr. Blonde, bickering weasel Mr. Pink and Nice Guy Eddie -- unravel.